Nabil G. Seidah

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in Canada Leader Award
• 2025 - Research.com Biology and Biochemistry in Canada Leader Award
• 2023 - Research.com Biology and Biochemistry in Canada Leader Award
• 1992 - Fellow of the Royal Society of Canada Academy of Science

Overview

Best Publications

• Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.

  Marianne Abifadel;Mathilde Varret;Jean-Pierre Rabès;Delphine Allard

  3453
  Citations

• Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

  Martin J Vincent;Eric Bergeron;Suzanne Benjannet;Bobbie R Erickson

  2120
  Citations

• The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.

  B. Coutard;C. Valle;X. de Lamballerie;B. Canard

  1785
  Citations

• The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation

  Nabil G. Seidah;Suzanne Benjannet;Louise Wickham;Jadwiga Marcinkiewicz

  1449
  Citations

• The Notch1 receptor is cleaved constitutively by a furin-like convertase

  Frédérique Logeat;Christine Bessia;Christel Brou;Odile LeBail

  1041
  Citations

• Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.

  Nabil G Seidah;Michel Chrétien

  921
  Citations

• Automated design of ligands to polypharmacological profiles

  Jérémy Besnard;Gian Filippo Ruda;Vincent Setola;Keren Abecassis

  907
  Citations

• The biology and therapeutic targeting of the proprotein convertases

  Nabil G. Seidah;Annik Prat

  871
  Citations

• NARC-1/PCSK9 and Its Natural Mutants ZYMOGEN CLEAVAGE AND EFFECTS ON THE LOW DENSITY LIPOPROTEIN (LDL) RECEPTOR AND LDL CHOLESTEROL

  Suzanne Benjannet;David Rhainds;Rachid Essalmani;Janice Mayne

  772
  Citations

• PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

  S Benjannet;N Rondeau;R Day;M Chrétien

  768
  Citations

• Statins Upregulate PCSK9, the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia

  Geneviève Dubuc;Ann Chamberland;Hanny Wassef;Jean Davignon

  744
  Citations

• Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor

  S J Mowla;H F Farhadi;H F Farhadi;S Pareek;S Pareek;J K Atwal;J K Atwal

  713
  Citations

• PCSK9: A Key Modulator of Cardiovascular Health

  Nabil G. Seidah;Zuhier Awan;Michel Chrétien;Majambu Mbikay

  640
  Citations

• Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.

  N. G. Seidah;M. Marcinkiewicz;S. Benjannet;L. Gaspar

  635
  Citations

• cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.

  N.G. Seidah;L. Gaspar;P. Mion;M. Marcinkiewicz

  596
  Citations

• The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2

  Steve Poirier;Gaetan Mayer;Suzanne Benjannet;Eric Bergeron

  548
  Citations

• The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.

  N.G. Seidah;M. Chrétien;R. Day

  489
  Citations

• Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase, GCN2

  Mauro Costa-Mattioli;Delphine Gobert;Heather Harding;Barbara Herdy

  481
  Citations

• Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

  Nabil G. Seidah;Suzanne Benjannet;Sangeeta Pareek;Michel Chrétien

  460
  Citations

• The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.

  Suzanne Benjannet;David Rhainds;Josée Hamelin;Nasha Nassoury

  452
  Citations